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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1949 1
1952 1
1954 1
1955 3
1957 1
1958 2
1959 2
1960 4
1961 8
1962 5
1963 7
1964 11
1965 15
1966 18
1967 34
1968 41
1969 39
1970 72
1971 68
1972 76
1973 69
1974 99
1975 351
1976 393
1977 320
1978 336
1979 355
1980 479
1981 557
1982 632
1983 745
1984 800
1985 870
1986 906
1987 930
1988 1061
1989 1152
1990 1290
1991 1369
1992 1559
1993 1691
1994 1695
1995 1860
1996 2015
1997 1814
1998 1780
1999 1899
2000 2032
2001 2170
2002 2187
2003 2148
2004 2271
2005 2301
2006 2328
2007 2384
2008 2351
2009 2405
2010 2410
2011 2438
2012 2504
2013 2527
2014 2551
2015 2490
2016 2340
2017 2489
2018 2564
2019 2396
2020 2515
2021 2403
2022 2293
2023 2111
2024 747

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78,440 results

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Page 1
A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.
Brittain RT, Levy GP. Brittain RT, et al. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):681-4. Br J Clin Pharmacol. 1976. PMID: 10948 Free article. Review.
Labetalol was 6-10 times less potent than phentolamine in blocking alpha-adrenoreceptors and 1.5-3 times less potent than propranolol in blocking beta-adrenoreceptors. ...Labetalol was about 7 times less potent than phentolamine in blocking alpha …
Labetalol was 6-10 times less potent than phentolamine in blocking alpha-adrenoreceptors and 1.5-3 times less potent than prop …
Targeting plasmodium alpha-tubulin-1 to block malaria transmission to mosquitoes.
Zhang G, Niu G, Hooker-Romera D, Shabani S, Ramelow J, Wang X, Butler NS, James AA, Li J. Zhang G, et al. Front Cell Infect Microbiol. 2023 Mar 16;13:1132647. doi: 10.3389/fcimb.2023.1132647. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37009496 Free PMC article.
We also generated mouse monoclonal antibodies (mAb) using recombinant P. falciparum alpha-tubulin-1. Out of 16 mAb, two mAb, A3 and A16, blocked P. falciparum transmission with EC(50) of 12 mug/ml and 2.8 mug/ml. The epitopes of A3 and A16 were determined to be a co …
We also generated mouse monoclonal antibodies (mAb) using recombinant P. falciparum alpha-tubulin-1. Out of 16 mAb, two mAb, A3 and A …
Potential vascular alpha(1)-adrenoceptor blocking properties of metformin in rat aorta and tail artery.
Álvarez-Cámara JF, Ramírez-Rosas MB, Medina-Terol GJ, Silva-Velasco DL, Velazco-Paz A, Sánchez-López A, Guzman-Priego CG, Osuna-Martínez U, Centurión D. Álvarez-Cámara JF, et al. Eur J Pharmacol. 2019 Sep 5;858:172498. doi: 10.1016/j.ejphar.2019.172498. Epub 2019 Jun 22. Eur J Pharmacol. 2019. PMID: 31238063
Since alpha(1)-adrenoceptors play a significant role to regulate vascular tone, this study has analysed the potential ability of metformin to block alpha(1)-adrenoceptors in rat aorta and tail artery. ...Interestingly, the contractile responses to noradrenali …
Since alpha(1)-adrenoceptors play a significant role to regulate vascular tone, this study has analysed the potential ability of metf …
Interaction between alpha- and beta-adrenoceptor-mediated cardiovascular effects.
van Zwieten PA. van Zwieten PA. J Cardiovasc Pharmacol. 1986;8 Suppl 4:S21-8. doi: 10.1097/00005344-198608004-00004. J Cardiovasc Pharmacol. 1986. PMID: 2427848 Review.
A survey is given of the mutual interaction of alpha- and beta-adrenoceptor mediated cardiovascular effects, with an emphasis on the effects of drugs which simultaneously block alpha- and beta-adrenoceptors. ...Celiprolol is an example of a drug which combine …
A survey is given of the mutual interaction of alpha- and beta-adrenoceptor mediated cardiovascular effects, with an emphasis on the …
Interaction of alpha- and beta-adrenergic receptor blocking agents: circulatory effects in the conscious rat.
Gomes C, Henning M, Persson B, Trolin G. Gomes C, et al. Clin Exp Hypertens (1978). 1978;1(2):141-65. doi: 10.3109/10641967809068601. Clin Exp Hypertens (1978). 1978. PMID: 39712
The hypotension was more pronounced than that seen after an acute cervical transection of the spinal cord or after hexamethonium treatment. The tachycardia was blocked by drugs with beta 1-receptor blocking capacity while the hypotensive response was blocked …
The hypotension was more pronounced than that seen after an acute cervical transection of the spinal cord or after hexamethonium treatment. …
Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.
Swantek JL, Cobb MH, Geppert TD. Swantek JL, et al. Mol Cell Biol. 1997 Nov;17(11):6274-82. doi: 10.1128/MCB.17.11.6274. Mol Cell Biol. 1997. PMID: 9343388 Free PMC article.
A kinase-defective mutant of SAPKbeta, SAPKbeta K-A, blocked translation of TNF-alpha, as determined by using a TNF-alpha translational reporting system. Finally, overexpression of wild-type SAPKbeta was able to overcome the dexamethasone-induced block …
A kinase-defective mutant of SAPKbeta, SAPKbeta K-A, blocked translation of TNF-alpha, as determined by using a TNF-alpha …
Alpha-blockade therapy for benign prostatic hyperplasia: from a nonselective to a more selective alpha1A-adrenergic antagonist.
Beduschi MC, Beduschi R, Oesterling JE. Beduschi MC, et al. Urology. 1998 Jun;51(6):861-72. doi: 10.1016/s0090-4295(98)00140-x. Urology. 1998. PMID: 9609620 Review.
In recent years, understanding of the sympathetic innervation of the prostate has improved. This has been paralleled by the development of alpha-adrenergic blocking agents, from nonselective alpha-antagonists, to selective alpha1-antagonists, to the more sele …
In recent years, understanding of the sympathetic innervation of the prostate has improved. This has been paralleled by the development of …
The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract.
Lahn M, Paterson BM, Sundell K, Ma D. Lahn M, et al. Eur J Cancer. 2004 Jan;40(1):10-20. doi: 10.1016/j.ejca.2003.08.020. Eur J Cancer. 2004. PMID: 14687784 Review.
One such "new targeted agent" is aprinocarsen, an antisense oligonucleotide that specifically blocks the mRNA of protein kinase C-alpha (PKC-alpha). Blocking PKC-alpha, an important cellular signalling molecule associated with tumour growth, is …
One such "new targeted agent" is aprinocarsen, an antisense oligonucleotide that specifically blocks the mRNA of protein kinase C- …
Five different profiles of dihydropyridines in blocking T-type Ca(2+) channel subtypes (Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I))) expressed in Xenopus oocytes.
Furukawa T, Nukada T, Namiki Y, Miyashita Y, Hatsuno K, Ueno Y, Yamakawa T, Isshiki T. Furukawa T, et al. Eur J Pharmacol. 2009 Jun 24;613(1-3):100-7. doi: 10.1016/j.ejphar.2009.04.036. Epub 2009 May 3. Eur J Pharmacol. 2009. PMID: 19401195
These 3 kinds (alpha(1H), alpha(1I) and alpha(1G)) of T-type channels were blocked by amlodipine, manidipine and nicardipine. On the other hand, azelnidipine, barnidipine, benidipine and efonidipine significantly blocked alpha(1H) and …
These 3 kinds (alpha(1H), alpha(1I) and alpha(1G)) of T-type channels were blocked by amlodipine, manidipine and …
Wild-type GBA1 increases the alpha-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Glajch KE, et al. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2103425118. doi: 10.1073/pnas.2103425118. Proc Natl Acad Sci U S A. 2021. PMID: 34326260 Free PMC article.
Altered lipid metabolism in PD patient-derived neurons, carrying either GBA1 or PD alphaS mutations, can shift the physiological alpha-synuclein (alphaS) tetramer-monomer (T:M) equilibrium toward aggregation-prone monomers. A resultant increase in pSer129+ …
Altered lipid metabolism in PD patient-derived neurons, carrying either GBA1 or PD alphaS mutations, can shift the physiological a …
78,440 results
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